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A Simple and Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles

Kiumars Bahrami*, Mohammad Mehdi Khodaei*, Iman Kavianinia

*Department of Chemistry, Razi University, Kermanshah 67149, Iran, Email:,

K. Bahrami, M. M. Khodaei, I. Kavianinia, Synthesis, 2007, 417-427.

DOI: 10.1055/s-2007-965878


A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H2O2 and HCl in acetonitrile at room temperature features short reaction time, easy and quick isolation of the products, and excellent yields.

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proposed mechanism

Mild and Highly Efficient Method for the Synthesis of 2-Arylbenzimidazoles and 2-Arylbenzothiazoles

K. Bahrami, M. M. Khodaei, F. Naali, J. Org. Chem., 2008, 73, 6835-6837.

Key Words

o-phenylenediamines, benzimidazoles, aryl aldehydes, hydrogen peroxide

ID: J66-Y2007-0600