A Simple and Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles
Kiumars Bahrami*, Mohammad Mehdi Khodaei*, Iman Kavianinia
*Department of Chemistry, Razi University, Kermanshah 67149, Iran, Email: k2005bahramiyahoo.com, mmkhodarazi.ac.ir
K. Bahrami, M. M. Khodaei, I. Kavianinia, Synthesis, 2007, 417-427.
A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H2O2 and HCl in acetonitrile at room temperature features short reaction time, easy and quick isolation of the products, and excellent yields.
see article for more examples
K. Bahrami, M. M. Khodaei, F. Naali, J. Org. Chem., 2008, 73, 6835-6837.