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Efficient Method for the Synthesis of Chiral Pyrrolidine Derivatives via Ring-Closing Enyne Metathesis Reaction

Qian Yang, Howard Alper* and Wen-Jing Xiao

*Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada, Email:

Q. Yang, H. Alper, W.-J Xiao, Org. Lett., 2007, 9, 769-771.

DOI: 10.1021/ol062959i


A series of new pyrrolidine derivatives were prepared directly in very good yields, from substrates containing a basic or nucleophilic N atom via ring-closing enyne metathesis reaction under mild reaction conditions.

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Key Words

Enyne Metathesis, Olefin Metathesis, 3-Pyrrolines

ID: J54-Y2007-0710