Organic Chemistry Portal



Gold(I)-Catalyzed Enantioselective Intramolecular Hydroamination of Allenes

Rebecca L. LaLonde, Benjamin D. Sherry, Eun Joo Kang and F. Dean Toste*

*Department of Chemistry, University of California, Berkeley, California 94720, Email:

R. L. LaLonde, B. D. Sherry, E. J. Kang, F. D. Toste, J. Am. Chem. Soc., 2007, 129, 2452-2453.

DOI: 10.1021/ja068819l (free Supporting Information)


An asymmetric intramolecular hydroamination of allenes catalyzed by phosphinegold(I)-bis-p-nitrobenzoate complexes is applicable to the enantioselective formation of vinyl pyrrolidines and piperidines in high ee.

see article for more reactions

see article for more examples

Key Words

Hydroamination, Pyrrolidines, Piperidines, Allenes

ID: J48-Y2007-0750