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Gold(I)-Catalyzed Enantioselective Intramolecular Hydroamination of Allenes

Rebecca L. LaLonde, Benjamin D. Sherry, Eun Joo Kang and F. Dean Toste*

*Department of Chemistry, University of California, Berkeley, California 94720, Email: fdtosteberkeley.edu

R. L. LaLonde, B. D. Sherry, E. J. Kang, F. D. Toste, J. Am. Chem. Soc., 2007, 129, 2452-2453.

DOI: 10.1021/ja068819l (free Supporting Information)


 

Abstract

An asymmetric intramolecular hydroamination of allenes catalyzed by phosphinegold(I)-bis-p-nitrobenzoate complexes is applicable to the enantioselective formation of vinyl pyrrolidines and piperidines in high ee.

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Key Words

Hydroamination, Pyrrolidines, Piperidines, Allenes


ID: J48-Y2007-0750