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Catalytic One-Pot, Three-Component Acyl-Strecker Reaction

Subhas Chandra Pan, Benjamin List*

*Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany, Email:

S. C. Pan, B. List, Synlett, 2007, 318-320.

DOI: 10.1055/s-2007-968008


Different aldehydes and amines react with acyl cyanides in the presence of a catalytic amount of the Schreiner thiourea catalyst to give the corresponding N-acyl amino nitriles in high yields. The scope of the reaction is broad and allows the use of both aromatic and aliphatic aldehydes and amines.

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Key Words

acylcyanation, α-amino nitriles, organocatalysis, acyl cyanides, Strecker reaction

ID: J60-Y2007-0850