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Direct C-Arylation of β-Enamino Esters and Ketones with Arynes

Yeeman K. Ramtohul* and Anik Chartrand

*Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., Inc., P.O. Box 1005, 16711 Trans Canada Highway, Kirkland, Quebec, Canada H9H 3L1, Email:

Y. K. Ramtohul, A. Chartrand, Org. Lett., 2007, 9, 1029-1032.

DOI: 10.1021/ol063057k (free Supporting Information)


An efficient, mild, and general method for the C-arylation of β-enamino esters and ketones with arynes provides a facile and direct access to various substituted aromatic β-enamino compounds in good yield.

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Key Words

α-Arylation, Enamines, β-Enamino Esters, β-Enamino Ketones

ID: J54-Y2007-0870