Direct Intermolecular Hydroacylation of N,N-Dialkylacrylamides with Aldehydes Catalyzed by a Cationic Rhodium(I)/dppb Complex
Ken Tanaka,* Yu Shibata, Takeshi Suda, Yuji Hagiwara and Masao Hirano
*Department of Applied Chemistry, Graduate School of Engineering, and Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan, Email: tanaka-kcc.tuat.ac.jp
K. Tanaka, Y. Shibata, T. Suda, Y. Hagiwara, M. Hirano, Org. Lett., 2007, 9, 1215-1218.
DOI: 10.1021/ol070153s (free Supporting Information)
A cationic rhodium(I)/dppb complex catalyzed direct intermolecular hydroacylation of N,N-dialkylacrylamides with both aliphatic and aromatic aldehydes represents a versatile route to γ-ketoamides in view of high atom economy and commercial availability of substrates.
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Y. Shibata, K. Tanaka, J. Am. Chem. Soc., 2009, 131, 12552-12553.