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A New Versatile Synthesis of Esters from Grignard Reagents and Chloroformates

Daniela Bottalico, Vito Fiandanese, Giuseppe Marchese, Angela Punzi*

*Dipartimento di Chimica, UniversitÓ di Bari, Via Orabona 4, 70126 Bari, Italy, Email:

D. Bottalico, V. Fiandanese, G. Marchese, A. Punzi, Synlett, 2007, 974-976.

DOI: 10.1055/s-2007-973861


An efficient cross-coupling reaction of chloroformates with organocopper reagents, derived from Grignard reagents, cuprous bromide and lithium bromide, provides esters in good yields.

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Key Words

organometallic reagents, cross-coupling, chemoselectivity, esters

ID: J60-Y2007-1040