Synthesis of Substituted 2,2'-Bipyridines from 2-Bromo- or 2-Chloropyridines Using Tetrakis(triphenylphosphine)palladium(0) as a Catalyst in a Modified Negishi Cross-Coupling Reaction
U. Kiehne, J. Bunzen, H. Staats, A. Lützen*
*University of Bonn, Kekulé-Institute of Organic Chemistry and Biochemistry,
Gerhard-Domagk-Str. 1, 53121 Bonn, Germany, Email: arne.luetzen
uni-bonn.de
U. Kiehne, J. Bunzen, H. Staats, A. Lützen, Synthesis, 2007, 1061-1069.
DOI: 10.1055/s-2007-965952
Abstract
An efficient and mild Negishi cross-coupling strategy for substituted 2,2′-bipyridines uses tetrakis(triphenylphosphine)palladium(0) as a simple, commercially available, and relatively inexpensive catalyst for both 2-bromo- and 2-chloropyridines.
see article for more examples
A. Lützen, M. Hapke, Eur. J. Org. Chem., 2002, 2292-2297.
Key Words
heterobiaryls, 2,2'-bipyridines, Negishi coupling, cross-coupling reactions, organozinc compounds, palladium
ID: J66-Y2007-1070
