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Synthesis and Characterization of R2PN=P(iBuNCH2CH2)3N: A New Bulky Electron-Rich Phosphine for Efficient Pd-Assisted Suzuki-Miyaura Cross-Coupling Reactions

Jesudoss V. Kingston and John G. Verkade*

*Department of Chemistry, Iowa State University, Ames, Iowa 50011, Email:

J. V. Kingston, J. G. Verkade, J. Org. Chem., 2007, 72, 2816-2822.

DOI: 10.1021/jo062452l (free Supporting Information)


A catalyst system of sterically bulky electron-rich phosphines and Pd(OAc)2 was particularly efficient for the coupling of arylboronic acids with aryl bromides as well as aryl chlorides to give biaryls in excellent yields.

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Key Words

Suzuki Coupling, Biaryls

ID: J42-Y2007-1090