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Copper-Catalyzed Highly Efficient Multicomponent Reactions: Synthesis of 2-(Sulfonylimino)-4-(alkylimino)azetidine Derivatives

Xiaoliang Xu,* Dongping Cheng, Jinghua Li, Hongyun Guo and Jie Yan

*College of Chemical Engineering and Materials Science and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China, Email:

X. Xu, D. Cheng, J. Li, H. Guo, J. Yan, Org. Lett., 2007, 9, 1585-1587.

DOI: 10.1021/ol070485x (free Supporting Information)


Functionalized 2-(sulfonylimino)-4-(alkylimino)azetidine derivatives were prepared in good to excellent yields via a copper-catalyzed multicomponent reaction of readily available terminal alkynes, sulfonyl azides, and carbodiimides without the assistance of a base under very mild conditions.

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Key Words

Azetidines, Multicomponent Reactions

ID: J54-Y2007-1220