Copper-Catalyzed Highly Efficient Multicomponent Reactions: Synthesis of 2-(Sulfonylimino)-4-(alkylimino)azetidine Derivatives
Xiaoliang Xu,* Dongping Cheng, Jinghua Li, Hongyun Guo and Jie Yan
*College of Chemical Engineering and Materials Science and College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China, Email: xuxiaoliangzjut.edu.cn
X. Xu, D. Cheng, J. Li, H. Guo, J. Yan, Org. Lett., 2007, 9, 1585-1587.
DOI: 10.1021/ol070485x (free Supporting Information)
Functionalized 2-(sulfonylimino)-4-(alkylimino)azetidine derivatives were prepared in good to excellent yields via a copper-catalyzed multicomponent reaction of readily available terminal alkynes, sulfonyl azides, and carbodiimides without the assistance of a base under very mild conditions.
see article for more examples