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An Improved Procedure for the Three-Component Synthesis of Highly Substituted Pyridines Using Ionic Liquid

Brindaban C. Ranu,* Ranjan Jana and S. Sowmiah

*Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India, Email:

B. C. Ranu, R. Jana, S. Sowmiah, J. Org. Chem., 2007, 72, 3152-3154.

DOI: 10.1021/jo070015g (free Supporting Information)


[bmim]OH, a basic ionic liquid, efficiently promotes a one-pot condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields. The ionic liquid can be recovered and recycled.

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proposed mechanism

Key Words

Pyridines, Multicomponent Reactions

ID: J42-Y2007-1230