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Solvent-Free Synthesis of Racemic α-Aminonitriles

Alejandro Baeza, Carmen Nájera*, José M. Sansano

*Departamento de Química Orgánica and Instituto de Síntesis Orgánica (ISO), Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain, Email:

A. Baeza, C. Nájera, J. M. Sansano, Synthesis, 2007, 1230-1234.

DOI: 10.1055/s-2007-965974


A very fast, simple one-step, environmentally friendly procedure for the synthesis of α-aminonitriles in high yields from aldehydes, using trimethylsilyl cyanide in the absence of solvent, gives almost quantitative yields of the corresponding α-aminonitriles. However, only cyclic ketones afford the corresponding α-aminonitriles in excellent chemical yields.

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Key Words

addition reactions, Strecker synthesis, catalysis, aminonitriles, green chemistry, solvent-free

ID: J66-Y2007-1270