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Asymmetric Conjugate Alkenylation of Enones Catalyzed by Chiral Diols

T. Robert Wu and J. Michael Chong*

*Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1, Email:

T. R. Wu, J. M. Chong, J. Am. Chem. Soc., 2007, 129, 4908-4909.

DOI: 10.1021/ja0713734


Conjugate addition of dimethyl alkenylboronates to α,β-unsaturated ketones in the presence of catalytic amounts of 3,3'-disubstituted binaphthols provides alkenylation products in good yields and high enantioselectivities.

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Key Words

Conjugate Addition, Alkenylation, Organocatalysis

ID: J48-Y2007-1290