Organic Chemistry Portal



Synthesis of Pyrroles via Copper-Catalyzed Coupling of Amines with Bromoenones

Yuanjia Pan, Hongjian Lu, Yewen Fang, Xinqiang Fang, Liqun Chen, Junlu Qian, Junhua Wang, Chaozhong Li*

*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. of China, Email:

Y. Pan, H. Lu, Y. Fang, X. Fang, L. Chen, J. Qian, J. Wang, C. Li, Synthesis, 2007, 1242-1246.

DOI: 10.1055/s-2007-965980


The CuI/N,N-dimethylglycine-catalyzed reaction of amines with γ-bromo-substituted γ,δ-unsaturated ketones in the presence of K3PO4 and NH4OAc gave the corresponding polysubstituted pyrroles in very good yields.

see article for more examples

Key Words

Ullmann-type reaction, amines, pyrroles, ammonium acetate

ID: J66-Y2007-1310