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Zinc(II) Perchlorate Hexahydrate Catalyzed Opening of Epoxide Ring by Amines: Applications to Synthesis of (RS)/(R)-Propranolols and (RS)/(R)/(S)-Naftopidils

Shivani, Brahmam Pujala and Asit K. Chakraborti*

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar 160 062, Punjab, India, Email: akchakrabortiniper.ac.in

Shivani, B. Pujala, A. K. Chakraborti, J. Org. Chem., 2007, 72, 3713-3722.

DOI: 10.1021/jo062674j (free Supporting Information)


Abstract

Zinc(II) perchlorate hexahydrate is a highly efficient catalyst for the opening of epoxides by amines affording 2-amino alcohols in high yields under solvent-free conditions and with excellent chemo-, regio-, and stereoselectivities.

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An efficient synthesis of 2-amino alcohols by silica gel catalysed opening of epoxide rings by amines

A. K. Chakraborti, S. Rudrawar, A. Kondaskar, Org. Biomol. Chem., 2004, 2, 1277-1280.


Key Words

2-amino alcohols


ID: J42-Y2007-1370