Synthesis of a Fluorous Ligand and Its Application for Asymmetric Addition of Dimethylzinc to Aldehydes
Yasser S. Sokeirik, Hiroyuki Mori, Masaaki Omote, Kazuyuki Sato, Atsushi Tarui, Itsumaro Kumadaki and Akira Ando*
*Faculty of Pharmaceutical Sciences, Setsunan University, 45-1,
Nagaotoge-cho, Hirakata, 573-0101 Japan, Email: aando
pharm.setsunan.ac.jp
Y. S. Sokeirik, H. Mori, M. Omote, K. Sato, A. Tarui, I. Kumadaki, A. Ando, Org. Lett., 2007, 9, 1927-1929.
DOI: 10.1021/ol070466n
Abstract
A new fluorous ligand showed excellent asymmetric induction on the addition of dimethylzinc to aldehydes. This ligand can be conveniently recycled and will be useful for synthesis of bioactive compounds with a methyl carbinol moiety.
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Key Words
Addition, FPOS, Fluorous
ID: J54-Y2007-1400
