An Efficient and Chemoselective Iron Catalyst for the Hydrogenation of Ketones
Charles P. Casey* and Hairong Guan
*Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, Email:
casey
chem.wisc.edu
C. P. Casey, H. Guan, J. Am. Chem. Soc., 2007, 129, 5816-5817.
DOI: 10.1021/ja071159f
Abstract
An iron complex containing electronically coupled acidic and hydridic hydrogens catalyzes the hydrogenation of ketones under mild conditions and shows high chemoselectivity for aldehydes, ketones, and imines. Isolated carbon double and triple bonds, aryl halides, nitrates, epoxides, and ester functions are unaffected by the hydrogenation conditions.
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Key Words
reduction of carbonyl compounds, iron (low valent), hydrogen
ID: J48-Y2007-1450
