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A New Construction of 2-Alkoxypyrans by an Acylation-Reductive Cyclization Sequence

Lars V. Heumann and Gary E. Keck*

*Department of Chemistry, University of Utah, 315 South 1400 East RM 2020, Salt Lake City, Utah 84112-0850, Email:

L. V. Heumann, G. E. Keck, Org. Lett., 2007, 9, 1951-1954.

DOI: 10.1021/ol070573h

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A new convergent synthetic approach to the 2-hydroxypyran motif common to many naturally occurring structures includes the esterification of two fragments and a subsequent intramolecular reductive cyclization.

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Key Words

Tetrahydropyrans, Samarium Diiodide

ID: J54-Y2007-1470