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Guanidine/Pd(OAc)2-Catalyzed Room Temperature Suzuki Cross-Coupling Reaction in Aqueous Media under Aerobic Conditions

Shenghai Li, Yingjie Lin, Jungang Cao and Suobo Zhang*

*State Key Laboratory of Polymer and Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, China, Email:

S. Li, Y. Lin, J. Cao, S. Zhang, J. Org. Chem., 2007, 72, 4067-4072.

DOI: 10.1021/jo0626257 (free Supporting Information)


A highly efficient, air-stable catalyst Pd(OAc)2/guanidine couples arylboronic acids with a wide range of aryl halides in aqueous solvent at room temperature to afford biaryls in good to excellent yields. Furthermore, this mild protocol tolerates a broad range of functional groups.

see article for more examples

Brønsted Guanidine Acid-Base Ionic Liquids: Novel Reaction Media for the Palladium-Catalyzed Heck Reaction

S. Li, Y. Lin, H. Xie, S. Zhang, J. Xu, Org. Lett., 2006, 8, 391-394.

Key Words

Suzuki Coupling, Biaryls, Green Chemistry

ID: J42-Y2007-1520