Catalytic Asymmetric Formation of β-Sultams
Marian Zajac and René Peters*
*Institut für Organische Chemie, Pfaffenwaldring 55, 70569
Stuttgart, Germany, Email: rene.peters
oc.uni-stuttgart.de
M. Zajac, R. Peters, Org. Lett., 2007, 9, 2007-2010.
DOI: 10.1021/ol070644c
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Abstract
Highly strained β-sultams, sulfonyl analogues of β-lactams, were prepared enantio- and diastereoselectively by tertiary amine catalyzed [2 + 2] cycloaddition reactions. β-Sultams are practical precursors of highly enantioenriched β-aminosulfonyl derivatives of biological interest.
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proposed mechanism
Key Words
ID: J54-Y2007-1530
