Stereoselective Synthesis of E-Vinyl Sulfides from Alkynes in Water under Neutral Conditions Using β-Cyclodextrin
R. Sridhar, K. Surendra, N. Srilakshmi Krishnaveni, B. Srinivas, K. Rama Rao*
*Organic Chemistry Division-I, Indian Institute of Chemical Technology,
Hyderabad 500007, India, Email: drkrrao
yahoo.com
R. Sridhar, K. Surendra, N. S. Krishnaveni, B. Srinivas, K. R. Rao, Synlett, 2006, 3495-3497.
Abstract
A hydrothiolation of aromatic alkynes with thiophenols by anti-Markonikov addition in the presence of β-cyclodextrin in water gives E-vinyl sulfides in excellent yields. β-Cyclodextrin can be recovered and reused for a number of runs without any loss of activity.
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Key Words
β-cyclodextrin, E-vinyl sulfides, aromatic alkynes, thiophenols, water, green chemistry
ID: J60-Y2006-4860
