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An Efficient New Procedure for the One-Pot Conversion of Aldehydes into the Corresponding Nitriles

Jia-Liang Zhu, Fa-Yen Lee, Jen-Dar Wu, Chun-Wei Kuo, Kak-Shan Shia*

*Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 350, Taiwan, R.O.C., Email:

J.-L. Zhu, F.-Y. Lee, J.-D. Wu, C.-W. Kuo, K.-S. Shia, Synlett, 2007, 1317-1319.

DOI: 10.1055/s-2007-980338


An ethyl dichlorophosphate/DBU-mediated dehydration of aldoxime intermediates from aldehydes enables a new and efficient one-pot conversion of various aldehydes into the corresponding nitriles under mild reaction conditions.

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Key Words

aldehydes, nitriles, ethyl dichlorophosphate, DBU, dehydration

ID: J60-Y2007-1730