α-Amidation of Cyclic Ethers Catalyzed by Simple Copper Salt and a Mild and Efficient Preparation Method for α,ϖ-Amino Alcohols
Ling He, Jing Yu, Ji Zhang and Xiao-Qi Yu*
*Department of Chemistry, Key Laboratory of Green Chemistry
and Technology (Ministry of Education), Sichuan University, Chengdu, 610064,
People's Republic of China, Email: xqyu
tfol.com
L. He, J. Yu, J. Zhang, X.-Q. Yu, Org. Lett., 2007, 9, 2277-2280.
DOI: 10.1021/ol070537i
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Abstract
Copper(II) trifluoromethanesulfonate catalyzed a mild amidation of cyclic ethers with iminoiodanes with good yields and selectivity. A subsequent reductive ring-opening of the tosylamidated products gives α,ϖ-amino alcohols.
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Key Words
Amidation, Amino Alcohols, Iodosobenzene Diacetate, Sodium Borohydride
ID: J54-Y2007-1800
