Neutral π-Nucleophile-Catalyzed Cyanation of Aldehydes and Ketones

Xiu Wang, Shi-Kai Tian*

*Department of Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui 230026, P. R. of China, Email: tianskustc.edu.cn

X. Wang, S.-K. Tian, Synlett, 2007, 1416-1420.

DOI: 10.1055/s-2007-980366

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Abstract

1-Methoxy-2-methyl-1-(trimethylsiloxy)propene, a neutral π-nucleophile, is able to efficiently catalyze cyanosilylations and cyanocarbonations of various aldehydes and ketones.

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Key Words

π-nucleophile, organocatalysis, cyanosilylation, cyanocarbonation, cyanohydrins, aldehydes, ketones

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ID: J60-Y2007-1850