Organic Chemistry Portal



Thiourea-Catalyzed Transfer Hydrogenation of Aldimines

Zhiguo Zhang, Peter R. Schreiner*

*Institut für Organische Chemie, Justus-Liebig-Universität Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany, Email:

Z. Zhang, P. R. Schreiner, Synlett, 2007, 1455-1457.

DOI: 10.1055/s-2007-980349


A thiourea-catalyzed transfer hydrogenation of various aromatic as well as aliphatic aldimines through hydrogen-bonding activation with Hantzsch 1,4-dihydropyridine as the hydrogen source gives the respective amines under acid- and metal-free reaction conditions.

see article for more examples

Key Words

Hantzsch dihydropyridine, hydrogen bonds, organocatalysis, thiourea, transfer hydrogenation

ID: J60-Y2007-1890