Thia-Michael Addition Using Cheap and Odorless S-Alkylisothiouronium Salts as Thiol Equivalents in Water
Yan Zhao, Ze-Mei Ge*, Tie-Ming Cheng, Run-Tao Li
*School of Pharmaceutical Sciences, Peking University,
Beijing 100083, P. R. of China, Email: zmge
bjmu.edu.cn
Y. Zhao, Z.-M. Ge, T.-M. Cheng, R.-T. Li, Synlett, 2007, 1529-1532.
DOI: 10.1055/s-2007-982530
Abstract
S-Alkylisothiouronium salts are a nontoxic, odorless and simply operational alternative of thiols for the thia-Michael addition with electron-deficient olefins. The reactions were carried out under alkaline conditions in water at room temperature within short reaction times to afford the expected products in good yields.
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Key Words
thia-Michael addition, thiol equivalent, S-alkylisothiouronium salts, electron-deficient olefins, green chemistry
ID: J60-Y2007-1920
