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A Practical Synthesis of 2,4(5)-Diarylimidazoles from Simple Building Blocks

Valentina Zuliani, Giuseppe Cocconcelli,* Marco Fantini, Chiara Ghiron and Mirko Rivara

*Dipartimento Farmaceutico, Universitá degli Studi di Parma, V. le G.P. Usberti, 27/A, I-43100 Parma, Italy and Siena Biotech S.p.A., Via Fiorentina, 1, I-53100 Siena, Italy, Email: gcocconcellisienabiotech.it

V. Zuliani, G. Cocconcelli, M. Fantini, C. Ghiron, M. Rivara, J. Org. Chem., 2007, 72, 4551-4553.

DOI: 10.1021/jo070187d (free Supporting Information)


Abstract

A simple and efficient approach allows the preparation of biologically active 2,4(5)-diarylimidazoles by parallel synthesis. The formation of 2-aroyl-4(5)-arylimidazoles as side products strongly depends on the reaction conditions employed.

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Key Words

Imidazoles


ID: J42-Y2007-1940