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Cross-Coupling of Alkynylsilanols with Aryl Halides Promoted by Potassium Trimethylsilanolate

Scott E. Denmark* and Steven A. Tymonko

*Roger Adams Laboratory, Department of Chemistry University of Illinois, Urbana, Illinois 61801, Email:

S. E. Denmark, S. A. Tymonko, J. Org. Chem., 2003, 68, 9151-9154.

DOI: 10.1021/jo0351771


The palladium-catalyzed cross-coupling of aliphatic alkynylsilanols with aryl iodides proceeds at room temperature in very good yield with potassium trimethylsilanolate as the coupling promoter and copper(I) iodide as a cocatalyst.

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Key Words

Hiyama-Denmark Coupling, Alkynylation

ID: J42-Y2003-2210