Organic Chemistry Portal



A Catalytic Method for the Reduction of Secondary and Tertiary Phosphine Oxides

Mikaël Berthod, Alain Favre-Réguillon, Jahjah Mohamad, Gérard Mignani, Gordon Docherty, Marc Lemaire*

*Laboratoire de Catalyse et Synthèse Organique, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), CNRS, UMR5246, Université Lyon 1, 43 Boulevard du 11 Novembre 1918, 69622 Villeurbanne, France, Email:

M. Berthod, A. Favre-Réguillon, J. Mohamad, G. Mignani, G. Docherty, M. Lemaire, Synlett, 2007, 1545-1548.

DOI: 10.1055/s-2007-982536


TMDS is an efficient hydride source for the reduction of tertiary and secondary phosphine oxides using a catalytic amount of Ti(OiPr)4. All classes of tertiary phosphine oxides, such as triaryl, trialkyl, and diphosphine were effectively reduced.

see article for more examples

Key Words

phosphorus, reduction of phosphine oxides, titanium, hydrosiloxane, tetramethyldisiloxane, phosphine oxides

ID: J60-Y2007-1960