Facile Preparation of 2-Imidazolines from Aldehydes with tert-Butyl Hypochlorite
Midori Ishihara, Hideo Togo*
*Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan, Email: togofaculty.chiba-u.jp
M. Ishihara, H. Togo, Synthesis, 2007, 1939-1942.
An efficient preparation of 2-imidazolines was achieved from aldehydes and ethylenediamines in the presence of tert-butyl hypochlorite. By this method, 1,3-bis(imidazolin-2-yl)benzene and 2,6-bis(imidazolin-2-yl)pyridine, which act as chiral ligands, could be prepared directly from the corresponding dialdehydes in high yields.
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M. Ishihara, H. Togo, Synlett, 2006, 227-230.