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Facile Preparation of 2-Imidazolines from Aldehydes with tert-Butyl Hypochlorite

Midori Ishihara, Hideo Togo*

*Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan, Email:

M. Ishihara, H. Togo, Synthesis, 2007, 1939-1942.

DOI: 10.1055/s-2007-983726


An efficient preparation of 2-imidazolines was achieved from aldehydes and ethylenediamines in the presence of tert-butyl hypochlorite. By this method, 1,3-bis(imidazolin-2-yl)benzene and 2,6-bis(imidazolin-2-yl)pyridine, which act as chiral ligands, could be prepared directly from the corresponding dialdehydes in high yields.

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An Efficient Preparation of 2-Imidazolines and Imidazoles from Aldehydes with Molecular Iodine and (Diacetoxyiodo)benzene

M. Ishihara, H. Togo, Synlett, 2006, 227-230.

Key Words

2-imidazolines, tert-butyl hypochlorite, aldehydes, ethylenediamine

ID: J66-Y2007-2080