Catalytic Intermolecular Reductive Coupling of Enones and Alkynes
Ananda Herath, Benjamin B. Thompson and John Montgomery*
*Department of Chemistry, University of Michigan, 930 North
University Avenue, Ann Arbor, Michigan 48109-1055, Email: jmontg
umich.edu
A. Herath, B. B. Thompson, J. Montgomery, J. Am. Chem. Soc., 2007, 129, 8712-8713.
DOI: 10.1021/ja073300q
Abstract
A nickel-catalyzed intermolecular reductive coupling of enones and alkynes gives γ,δ-unsaturated ketones. The process does not require formation of a vinyl organometallic, and a variety of functional groups including free hydroxyls and esters are tolerated.
see article for more examples
Evolution of Efficient Strategies for Enone-Alkyne and Enal-Alkyne Reductive Couplings
W. Li, A. Herath, J. Montgomery, J. Am. Chem. Soc., 2009, 131, 17024-17029.
Highly Chemoselective and Stereoselective Synthesis of Z-Enol Silanes
A. Herath, J. Montgomery, J. Am. Chem. Soc., 2008, 130, 8132-8133.
Key Words
ID: J48-Y2007-2270
