Copper-Catalyzed Asymmetric Reduction of 3,3-Diarylacrylonitriles
Daehyung Lee, Youngmin Yang and Jaesook Yun*
*Department of Chemistry and Institute of Basic Science,
Sungkyunkwan University, Suwon 440-746, Korea, Email: jaesook
skku.edu
D. Lee, Y. Yang, J. Yun, Org. Lett., 2007, 9, 2749-2751.
DOI: 10.1021/ol0712071
Abstract
A range of 3-aryl-3-pyridylacrylonitriles were reduced with high levels of enantioselectivity under optimal conditions employing a copper/Josiphos complex in the presence of polymethylhydrosiloxane (PMHS).
see article for more examples
Highly Enantioselective Conjugate Reduction of β,β-Disubstituted α,β-Unsaturated Nitriles
D. Lee, D. Kim, S. Yun, Angew. Chem. Int. Ed., 2006, 45, 2785-2787.
Key Words
Reduction of α,β-unsaturated compounds, PMHS, Copper Hydride
ID: J54-Y2007-2290
