Catalytic Enantioselective Conia-Ene Reaction
Britton K. Corkey and F. Dean Toste*
*Department of Chemistry, University of California, Berkeley,
California 94720, Email: fdtoste
berkeley.edu
B. K. Corkey, F. D. Toste, J. Am. Chem. Soc., 2005, 127, 17168-17169.
DOI: 10.1021/ja055059q
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Abstract
An enantioselective Conia-ene reaction of acetylenic β-dicarbonyl compounds employs a DTBMSegphos-Pd(II)/Yb(III) dual catalyst system that allows for the asymmetric synthesis of all-carbon quaternary centers and generates a methylene cyclopentane containing an alkene that can be further manipulated.
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Gold(I)-Catalyzed Conia-Ene Reaction of β-Ketoesters with Alkynes
J. J. Kennedy-Smith, S. T. Staben, F. D. Toste, J. Am. Chem. Soc., 2004, 126, 4526-4527.
Key Words
Conia Ene Reaction, Active methylenes, Cyclopentanes
ID: J48-Y2004-3210
