Efficient Synthesis of 2-Substituted 7-Azaindole Derivatives via Palladium-Catalyzed Coupling and C-N Cyclization Using 18-Crown-6
Marcos Carlos de Mattos, Sergio Alatorre-Santamaría, Vicente Gotor-Fernández, Vicente Gotor*
*Departamento de Química Orgánica e Inorgánica, Instituto
Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo,
Spain, Email: vgs
fq.uniovi.es
M. C. de Mattos, S. Alatorre-Santamaría, V. Gotor-Fernández, V. Gotor, Synthesis, 2007, 2149-2152.
DOI: 10.1055/s-2007-983730
Abstract
A practical and straightforward preparation of various novel 2-substituted 7-azaindole derivatives from 2-amino-3-iodopyridine by a two-step procedure is described that gives the desired compounds in good overall yields.
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Key Words
alkynes, Sonogashira Coupling, 7-azaindoles, 18-crown-6, heterocycles, palladium catalysis
ID: J66-Y2007-2370
