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Efficient Synthesis of 2-Substituted 7-Azaindole Derivatives via Palladium-Catalyzed Coupling and C-N Cyclization Using 18-Crown-6

Marcos Carlos de Mattos, Sergio Alatorre-Santamaría, Vicente Gotor-Fernández, Vicente Gotor*

*Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain, Email:

M. C. de Mattos, S. Alatorre-Santamaría, V. Gotor-Fernández, V. Gotor, Synthesis, 2007, 2149-2152.

DOI: 10.1055/s-2007-983730


A practical and straightforward preparation of various novel 2-substituted 7-azaindole derivatives from 2-amino-3-iodopyridine by a two-step procedure is described that gives the desired compounds in good overall yields.

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Key Words

alkynes, Sonogashira Coupling, 7-azaindoles, 18-crown-6, heterocycles, palladium catalysis

ID: J66-Y2007-2370