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Easily Accessible and Highly Tunable Indolyl Phosphine Ligands for Suzuki-Miyaura Coupling of Aryl Chlorides

Chau Ming So, Chak Po Lau and Fuk Yee Kwong*

*Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, Email: bcfykinet.polyu.edu.hk

C. M. So, C. P. Lau, F. Y. Kwong, Org. Lett., 2007, 9, 2795-2798.

DOI: 10.1021/ol070898y (free Supporting Information)


Abstract

A new class of easily accessible indolyl phosphine ligands provides high potential of steric and electronic tunability. The air-stable indolyl phosphines in combination with a palladium metal precursor are effective catalysts for Suzuki-Miyaura coupling of unactivated aryl chlorides, and a catalyst loading down to 0.02 mol % can be achieved.

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A New Family of Tunable Indolylphosphine Ligands by One-Pot Assembly and Their Applications in Suzuki-Miyaura Coupling of Aryl Chlorides

C. M. So, C. C. Yeung, C. P. Lau, F. Y. Kwong, J. Org. Chem., 2008, 73, 7803-7806.

Suzuki-Miyaura Coupling of Aryl Tosylates Catalyzed by an Array of Indolyl Phosphine-Palladium Catalysts

C. M. So, C. P. Lau, A. S. C. Chan, F. Y. Kwong, J. Org. Chem., 2008, 73, 7731-7734.


Key Words

Suzuki Coupling, Biaryls


ID: J54-Y2007-2380