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Indium(III) Trifluoromethanesulfonate as an Efficient Catalyst for the Deprotection of Acetals and Ketals

Brian T. Gregg,* Kathryn C. Golden and John F. Quinn

*Department of Medicinal Chemistry, AMRI, Albany, New York 12203, Email:

B. T. Gregg, K. C. Golden, J. F. Quinn, J. Org. Chem., 2007, 72, 5890-5893.

DOI: 10.1021/jo0707075


Acetals and ketals are readily deprotected under neutral conditions in the presence of acetone and indium(III) trifluoromethanesulfonate as catalyst at room temperature or mild microwave heating conditions to give the corresponding aldehydes and ketones in good to excellent yields.

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Key Words

deprotection of acetals, cyclic acetals, dimethyl acetals, microwave synthesis

ID: J42-Y2007-2400