One-Pot Amidation of Olefins through Pd-Catalyzed Coupling of Alkylboranes and Carbamoyl Chlorides

Yoshizumi Yasui, Sayo Tsuchida, Hideto Miyabe and Yoshiji Takemoto*

*Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan, Email: takemotopharm.kyoto-u.ac.jp

Y. Yasui, S. Tsuchida, H. Miyabe, Y. Takemoto, J. Org. Chem., 2007, 72, 5898-5900.

DOI: 10.1021/jo070724u

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Abstract

Alkylboranes, generated by hydroboration of terminal olefins with 9-BBN-H, underwent smooth coupling with carbamoyl chlorides in the presence of palladium catalyst and Cs₂CO₃ to give C1-elongated amides.

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Key Words

hydroboration, amides

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ID: J42-Y2007-2420