Highly Enantioselective Synthesis of (E)-Allylic Alcohols
Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang*
*Department of Chemistry, National Tsing Hua University,
Hsinchu, Taiwan, 300, Republic of China, Email: bjuang
mx.nthu.edu.tw
H.-L. Wu, P.-Y. Wu, B.-J. Uang, J. Org. Chem., 2007, 72, 5935-5937.
DOI: 10.1021/jo0709403
Abstract
The asymmetric addition of alkenylzincs to aromatic and α-branched aliphatic aldehydes catalyzed by (-)-2-exo-morpholinoisoborne-10-thiol generated the corresponding (E)-allylic alcohols with >95% ee and very good chemical yields.
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Key Words
hydroboration, allylic alcohols
ID: J42-Y2007-2460
