Organic Chemistry Portal



An Efficient One-Pot Synthesis of Unsymmetrical Ethers: A Directly Reductive Deoxygenation of Esters Using an InBr3/Et3SiH Catalytic System

Norio Sakai,* Toshimitsu Moriya and Takeo Konakahara

*Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan, Email:

N. Sakai, T. Moriya, T. Konakahara, J. Org. Chem., 2007, 72, 5920-5922.

DOI: 10.1021/jo070814z


A novel one-pot procedure for a directly reductive conversion of esters to the corresponding ethers by Et3SiH in the presence of a catalytic amount of InBr3 is described. This simple catalytic system appeared to be remarkably tolerant to several functional groups.

see article for more examples

proposed mechanism

Key Words

reduction of esters, triethylsilane, indium

ID: J42-Y2007-2490