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Pd(OAc)2-Catalyzed Fluoride-Free Cross-Coupling Reactions of Arylsiloxanes with Aryl Bromides in Aqueous Medium

Shengyin Shi and Yuhong Zhang*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China, Email:

S. Shi, Y. Zhang, J. Org. Chem., 2007, 72, 5927-5930.

DOI: 10.1021/jo070855v (free Supporting Information)


A Pd(OAc)2-catalyzed, mild, fluoride-free cross-coupling between aryl bromides and arylsiloxanes in good to high yields has been achieved in aqueous medium in the presence of poly(ethylene glycol) (PEG) and sodium hydroxide. The product was easily separated with ethyl ether extraction, and the catalytic system can be reused eight times with high efficiency.

Phosphine-Free Palladium Acetate Catalyzed Suzuki Reaction in Water

L. Liu, Y. Zhang, Y. Wang, J. Org. Chem., 2005, 70, 6122-6125.

Key Words

Hiyama Coupling, Biaryls, Green Chemistry

ID: J42-Y2007-2500