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A Catalytic Synthesis of Aziridines without the Usual Byproducts

Arindam Mazumdar, Zheng Xue, Michael F. Mayer*

*Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA, Email:

A. Mazumdar, Z. Xue, M. F. Mayer, Synlett, 2007, 2025-2028.

DOI: 10.1055/s-2007-984872


Complementary to existing routes, Lewis acid catalyzed reactions of phenyldiazomethane with α-imino esters selectively produce cis-aziridine-2-carboxylates without competitive formation of enamino ester or carbene dimer byproducts.

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Key Words

catalysis, aziridines, diazo compounds, heterocycles, imines, Lewis acids

ID: J60-Y2007-2560