Direct Lactone Formation by Using Hypervalent Iodine(III) Reagents with KBr via Selective C-H Abstraction Protocol
Toshifumi Dohi, Naoko Takenaga, Akihiro Goto, Akinobu Maruyama and Yasuyuki Kita*
*Graduate School of Pharmaceutical Sciences, Osaka
University, 1-6 Yamada-oka, Suita, Osaka, 565-0871 Japan, Email: kita
phs.osaka-u.ac.jp
T. Dohi, N. Takenaga, A. Goto, A. Maruyama, Y. Kita, Org. Lett., 2007, 9, 3129-3132.
DOI: 10.1021/ol071315n
Abstract
A new and reliable method for the direct construction of biologically important aryl lactones and phthalides from carboxylic and benzoic acids is based on selective benzylic C-H abstraction in the presence of hypervalent iodine(III) reagents and KBr.
see article for more examples
proposed mechanism
Key Words
Lactones, Hypervalent Iodine Compounds
ID: J54-Y2007-2580
