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Cu-Catalyzed Tandem C-N Bond Formation for the Synthesis of Pyrroles and Heteroarylpyrroles

Rubén Martín, Catharine H. Larsen, Ana Cuenca and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

R. Martín, C. H. Larsen, A. Cuenca, S. L. Buchwald, Org. Lett., 2007, 9, 3379-3382.

DOI: 10.1021/ol7014225 (free Supporting Information)


A highly efficient Cu-catalyzed tandem C-N bond-forming reaction of 1,4-dihalo-1,3-dienes allows the synthesis of pyrroles and heteroarylpyrroles with a wide variety of functional groups and substitution patterns from readily available precursors.

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ID: J54-Y2007-2720