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Use of in Situ Isopropoxide Protection in the Metal-Halogen Exchange of Arylboronates

Qin Jiang, Meagan Ryan and Paul Zhichkin*

*AMRI, 26 Corporate Circle, P.O. Box 15098, Albany, New York, 12212, Email:

Q. Jiang, M. Ryan, P. Zhichkin, J. Org. Chem., 2007, 72, 6618-6620.

DOI: 10.1021/jo0710329 (free Supporting Information)


meta- and para-dibromoarenes can be converted to isopropoxide-protected bromo arylboronates. A subsequent metal-halogen exchange and reaction with an electrophile leads to functionalized arylboronates in a one-pot manner.

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ID: J42-Y2007-2730