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Highly Atom Efficient Guanylation of both Aromatic and Secondary Amines Catalyzed by Simple Lanthanide Amides

Qinghai Li, Shaowu Wang,* Shuangliu Zhou, Gaosheng Yang, Xiancui Zhu and Yuyu Liu

*Anhui Key Laboratory of Functional Molecular Solids, Institute of Organic Chemistry, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, People's Republic of China, Email:

Q. Li, S. Wang, S. Zhou, G. Yang, X. Zhu, Y. Liu, J. Org. Chem., 2007, 72, 6763-6767.

DOI: 10.1021/jo0709089


Simple lanthanide amides are highly efficient catalysts for the guanylation of both aromatic and secondary amines with a high activity under mild conditions. These catalysts are compatible with a wide range of solvents and substrates.

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ID: J42-Y2007-2760