Organic Chemistry Portal



Design of Axially Chiral Dicarboxylic Acid for Asymmetric Mannich Reaction of Arylaldehyde N-Boc Imines and Diazo Compounds

Takuya Hashimoto and Keiji Maruoka*

*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan, Email:

T. Hashimoto, K. Maruoka, J. Am. Chem. Soc., 2007, 129, 10054-10055.

DOI: 10.1021/ja0713375


An axially chiral dicarboxylic acid has been applied to a highly enantioselective Mannich reaction of arylaldehyde N-Boc imines and diazo compounds as a new class of chiral hydrogen-bonding catalyst.

see article for more examples

Key Words

Diazo Compounds, β-Amino Acids, Organocatalysis

ID: J48-Y2007-2780