Design of Axially Chiral Dicarboxylic Acid for Asymmetric Mannich Reaction of Arylaldehyde N-Boc Imines and Diazo Compounds
Takuya Hashimoto and Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan, Email: maruokakuchem.kyoto-u.ac.jp
T. Hashimoto, K. Maruoka, J. Am. Chem. Soc., 2007, 129, 10054-10055.
DOI: 10.1021/ja0713375 (free Supporting Information)
An axially chiral dicarboxylic acid has been applied to a highly enantioselective Mannich reaction of arylaldehyde N-Boc imines and diazo compounds as a new class of chiral hydrogen-bonding catalyst.
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