Practical Asymmetric Henry Reaction Catalyzed by a Chiral Diamine-Cu(OAc)2 Complex
Takayoshi Arai,* Masahiko Watanabe and Akira Yanagisawa
*Department of Chemistry, Graduate School of Science, Chiba University, Inage 263-8522, Japan, Email: taraifaculty.chiba-u.jp
T. Arai, M. Watanabe, A. Yanagisawa, Org. Lett., 2007, 9, 3595-3597.
DOI: 10.1021/ol7014362 (free Supporting Information)
A complex of a chiral diamine ligand and Cu(OAc)2 was a highly efficient catalyst for the Henry reaction, giving various nitroaldols with with over 90% ee. The reaction was performed in n-propyl alcohol at room temperature, and the Henry adducts were produced in high yield with excellent enantiomeric excess.
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