Highly Efficient Ruthenium-Catalyzed Oxime to Amide Rearrangement

Nathan A. Owston, Alexandra J. Parker and Jonathan M. J. Williams

*Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK, Email: j.m.j.williamsbath.ac.uk

N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 3599-3601.

DOI: 10.1021/ol701445n

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Abstract

A wide range of aldoximes has been converted into the corresponding amides in high yield and selectivity using the ruthenium-based catalyst Ru(PPh₃)₃(CO)H₂/dppe/TsOH with catalyst loading as low as 0.04 mol%.

see article for more examples

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Iridium-Catalyzed Conversion of Alcohols into Amides via Oximes

N. A. Owston, A. J. Parker, J. M. J. Williams, Org. Lett., 2007, 9, 73-75.

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Key Words

amides, rearrangements, oximes

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ID: J54-Y2007-2830