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N-Methylimidazole as a Promising Catalyst for the Aza-Michael Addition Reaction of N-Heterocycles

Bo Kai Liu, Qi Wu, Xue Qi Qian, De Shui Lv, Xian Fu Lin*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. of China, Email: llc123zju.edu.cn

B. K. Liu, Q. Wu, X. Q. Qian, D. S. Lv, X. F. Lin, Synthesis, 2007, 2653-2659.

DOI: 10.1055/s-2007-983816


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Abstract

N-Methylimidazole is a promising catalyst for aza-Michael reactions. Various N-heterocycles were introduced­ to α,β-unsaturated carbonyl compounds employing N-methylimidazole in a highly efficient, rapid and high yielding synthesis of N-heterocyclic derivatives.

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Key Words

N-methylimidazole, Michael additions, nucleophiles, imidazoles, heterocycles, α,β-unsaturated compounds


ID: J66-Y2007-2970