Diastereoselective Synthesis of 1-Aryl-2-Amino-Cyclopropane Carboxylates
Trude Melby, Rachael Anne Hughes, Tore Hansen*
*Department of Chemistry, University of Oslo, Sem Sælands vei 26, 0315 Oslo, Norway, Email: torehanskjemi.uio.no
T. Melby, R. A. Hughes, T. Hansen, Synlett, 2007, 2277-2279.
DOI: 10.1055/s-2007-985587
Abstract
Methyl 1-aryl-2-amino-cyclopropane carboxylates have been readily synthesized in high yields by Rh-catalyzed decomposition of aryldiazoacetates in the presence of N-vinylphthalimide. The reaction is highly trans-selective.
see article for more examples
Key Words
cyclopropanation, diastereoselective, rhodium, diazoacetates, amino-cyclopropanes
ID: J60-Y2007-3000